sorafenib sfb  (Macklin Inc)

Journal: The FEBS journal

Article Title: Identification of a co-target for enhancing efficacy of sorafenib in HCC through a quantitative modeling approach.

doi: 10.1111/febs.14641

Figure Lengend Snippet: Figure1: GSHnet overview (adapted from Reed paper [33]). The model consists of four modules namely (i) the Folate(1-C) cycle, (ii) the methionine cycle, (iii) trans-sulfuration steps and (iv) glutathione biosynthesis and utilization. Sorafenib (SFB) and sorafenib-M2 (SFB-M2) form are represented as hexagons. Metabolism of sorafenib produces H2O2 (represented as star) which further gets cleared through GSH module in our model. Enzymes associated with this are represented as ellipses and colored pink. Positive feedback regulation is shown as green dotted lines, while negative feedback regulation loops are in red dotted lines, and SAM/SAH mediated regulatory loops are shown in grey dotted lines. Full names of all the enzymes and substrates, as well as complete description of the model is provided in Supplementary table 1. A graphical abstract of whole model is shown in the inset.

Article Snippet: Experimental validation of model predictions Reagents, cell line and cell culture: SFB was purchased from Santa cruz.

Techniques:

Journal: PLoS ONE

Article Title: Regulation of Multidrug Resistance Proteins by Genistein in a Hepatocarcinoma Cell Line: Impact on Sorafenib Cytotoxicity

doi: 10.1371/journal.pone.0119502

Figure Lengend Snippet: Effect of GNT on sorafenib-induced cytotoxicity.

Article Snippet: Sorafenib (Sfb) was from Cayman Chemicals (Ann Arbor, MI, USA).

Techniques: Control